Cancers in General

What is cancer

Cancer is a disease caused by normal cells changing so that they grow in an uncontrolled way. The uncontrolled growth causes a lump called a tumour to form. If not treated, the tumour can cause problems in one or more of the following ways

  • Spreading into normal tissues nearby
  • Causing pressure on other body structures
  • Spreading to other parts of the body through the lymphatic system or bloodstream

Your body is made up of billions of tiny cells that can only be seen under a microscope. These cells are grouped together to make up the tissues and organs of our bodies. They are a bit like building blocks.

Diagram showing how normal cells make up the tissue in our body

Different types of body tissues are made up of different types of body cells. For example, there are bone cells in bone and breast cells in the breast.

Cancer cells are different to normal cells in several ways. They don't die if they move to another part of the body and

  • Cancer cells don't stop reproducing
  • Cancer cells don't obey signals from other cells
  • Cancer cells don't stick together
  • Cancer cells don't specialise, but stay immature

Tumours (lumps) can be benign or malignant. Benign means it is not cancer. Benign tumours

  • Usually grow quite slowly
  • Do not spread to other parts of the body
  • Usually have a covering made up of normal cells

Benign tumours are made up of cells that are quite similar to normal cells. They will only cause a problem if they

  • Grow very large
  • Become uncomfortable or unsightly
  • Press on other body organs
  • Take up space inside the skull (such as a brain tumour)
  • Release hormones that affect how the body works

Malignant tumours are made up of cancer cells. They

  • Usually grow faster than benign tumours
  • Spread into and destroy surrounding tissues
  • Spread to other parts of the body

The diagram below shows a tumour appearing in cells lining a body structure such as the bowel wall. The tumour grows through the layer holding the cells in place (the basement membrane) and spreads into the bloodstream.

Diagram showing a malignant tumour

It is the ability to spread that makes a cancer harmful. If a cancer is not treated, it can spread into the organs near to where it started growing. It can also damage other parts of the body that it spreads to.

The place where a cancer begins is called the primary cancer. Cancers may also spread into nearby body tissues. For example, lung cancer can spread to the lining of the chest (the pleura). Ovarian cancer can spread to the lining of the abdomen (the peritoneum). This is called locally advanced cancer.

Cancer cells can break away from the primary tumour and be carried in the blood or lymphatic system to other parts of the body. There they can start to grow into new tumours. Tumours from cancers that have spread are called secondary cancers or metastases (pronounced met-as-tah-seez). A cancer that has spread has metastasised. The diagram shows a primary bowel cancer that has spread to the liver.

Diagram showing a primary and a secondary cancer

The various organs of the body are made up of different types of cells. Any of these cell types can grow into a primary cancer. Different types of cancer behave very differently. The type of cancer affects whether it is

  • Likely to grow quickly or slowly
  • Likely to produce chemicals that change the way the body works
  • Likely to spread in the blood or lymph system
  • Likely to respond well to particular treatments

Cancer tests

This section is about some of the tests you may have when doctors are diagnosing or treating your cancer. You may also have these tests as part of your routine follow up once your treatment is over. There is information about more specific tests in the sections about the different types of cancer.

  • Barium X-ray
  • Blood tests
  • Bone marrow
  • Bone scan
  • CT scan
  • Cystoscopy
  • Endoscopy
  • ERCP

  • IVU
  • Lumbar puncture
  • MRI
  • PET
  • PET-CT
  • Ultrasound
  • X-ray

Preventing cancer

  • Reducing your risk of cancer
  • Stopping smoking
  • Healthy eating
  • Limiting your sun exposure

Cancer treatment

  • Cancer drugs
  • Chemotherapy
  • Radiotherapy
  • Surgery
  • Hormone therapy
  • Biological therapy
  • Transplants
  • Bisphosphonates

  How you have cancer drugs

Tablets or capsules - Injection or a drip into your vein - Central lines - PICC lines - Portacaths - Injection into your muscle - Injection under your skin - Syringe drivers - Suppositories - Stick on skin patches - Tablets you dissolve on or under your tongue - Treatment cycles

  Other treatments

Radiofrequency ablation (RFA) - Laser treatment - High frequency focused ultrasound (HIFU) - Photodynamic therapy (PDT) - Cryotherapy - Ultraviolet light treatment

Particular symptoms to look out for

The following symptoms can be caused by cancer, but they can also be caused by many less serious illnesses. There is information below about

  • A lump somewhere on your body
  • Changes in a mole on your skin
  • A cough or hoarseness that won't go away
  • A change in bowel habits
  • Unexplained night sweats
  • Any abnormal bleeding
  • A sore or ulcer that won’t heal
  • Difficulty passing urine
  • Unexplained weight loss
  • Unexplained pain
  • Feeling very tired all the time
  • Skin changes
  • Nipple changes
  • Breathlessness
  • Difficulty in swallowing or continuing indigestion

many symptoms can just as easily be symptoms of other illnesses or conditions that are much more common, and often less serious, than cancer. Be aware of what is normal for your body and look out for any changes. If you have a symptom that worries you or that is unusual for you, go to your GP for a check up.